Monday , March 1 2021

Who gets seriously ill with corona? Arlangan researchers find new risk factor



Some people who are infected with the coronary virus do not see anything. Others are seriously ill and should be treated as inpatients. about Risk factors Even today – a year after the global outbreak of the Kovid 19 epidemic – there is still no definitive explanation. Arlington researchers Now there is a mention of one Biomarker Was found, at Predict severe disease progression.

So far, one thing is certain: Adults are more likely to become seriously ill with Covid-19. Other factors, such as smoking, increase the risk of serious illness. Obesity can also lead to serious problems. However, there is still no consensus on the mechanisms that increase the risk of acute coronary heart disease. Individuals who do not belong to any risk group often become seriously ill.

Protein concentration indicates the path of the corona

Two doctors in Arlington – Drs. Dr. George Weber and Dr. Jayesh Phys, Deputy Clinical Director and Physician at the Surgical Clinic at Arlington University Hospital. Alan Benard, an employee of the surgical clinic, now hopes to identify the difficult leg. Therapy is even possible.

Together with other researchers on the cellular immunity to inflammation and cancer at Arlington University Hospital, they have an important point to make. Leading index Whether the virus infection was mild or severe was found to be: Immunbotenstoff Interleukin-3. The results of the study are published in the journal Nature Communications.

Interleukin-3 is a Pottery and Ceramics ProteinWhich Stimulates the human immune system. It stimulates the process of blood formation and is therefore used to promote blood formation after bone marrow transplantation, usually after anemia or chemotherapy.

Weber and Benard now point out in a study a Low interleukin-3 levels Often in blood plasma a Severe foot course of Covid-19 disease Join hands. Interleukin-3 plays a key role in organizing the body’s immune response. It stimulates its cells to produce CXCL12 protein at the site of inflammation – for example pneumonia triggered by SARS-Cov-2.

Therapy also seems possible

“This protein communicates with the plasmacytoid dendritic cells that normally circulate in the blood vessels. CXL 12 pushes them into the inflamed lungs. Therefore, they prevent the replication of viruses. Weber. in other words: Interleukin-3 indirectly enhances the body’s immune defenses and focuses on them.

Interleukin-3 levels can provide an important clue to a tight leg. To date, this assessment can only be based on rougher criteria such as age or pre-existing disease. “But people who do not belong to any risk group may have low levels of interleukin-3 in their blood. With this, a series of difficult foot courses has come as a surprise so far and adequate medical treatment may be delayed. Weber to consider.

Now, based on the study results, important decisions regarding the treatment of Kovid-19 patients can be made in advance. Even more so: from a perspective it is conceivable To develop immunotherapy, Interleukin-3 is used in the form of an inhaler to protect against lung virus infection.


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