Saturday , April 17 2021

The team of scientists described the mechanism of passive drug use in the health cells



PRAGUE Dr. Pavel Jungwirth of the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, in collaboration with colleagues from the Czech Republic and Germany, described an unknown mechanism of passive transport of peptides to cells without intermediaries. Simple transportation of medicines directly to cells is one of the goals of the pharmaceutical industry. The Institute informed her in a press release today. The results of the research were published in the United States National Academy of Sciences (PNAS).

The ability of short peptides to penetrate cells is first seen in HIV studies and is now used to transfer drugs to cells. So far, it is most often done through a transport bag, Vectors that separate from the cell membrane and surround the transport material. We have to re-release a medicinal molecule from a bag that, according to scientists, may be a technical complication for effective drug transportation.

The peptides can also pass into cells without passive energy. Tim Jungwirth, using fluorescence and electron microscopy and computer molecular simulation, discovered a membrane-induced mechanism induced by transfected peptides alone. However, according to Jungwirth, the practical use of the discovery can only be speculated.

Medications (Illustrative Photography)

Jungwirth has long worked with his team on molecular processes in the cell membrane, opening up new possibilities of controlling these processes and potentially more efficient ways of transferring drug molecules to the site of action.

Jungwirth has published more than 280 papers in international journals, including Science, Nature Chemistry and PNAS. He is also editor of The Journal of Physical Chemistry, published by the American Chemical Society. It also popularizes science in the Respect, Czech radio and Czech television.


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