Thousands of people are expected to leave from Friday, while the fair DIY Street Fair and Funky Ferndale arrive on the streets of the center this weekend.
"The do-it-yourself fair is for do-it-yourself and crafter," said Cindy Willcock, deputy director of the Downtown Development Authority. "Funky Ferndale is a little more eccentric than your traditional art fair."
This year the Ferndale art exhibition on Nine Mile Road from Woodward to Planavon has about 120 artists showing their works for sale.
Participants at the fair can take part in painting an "inclusiveness" mural in the city center or consult a watercolor painting project to create their own postcards hosted by the Detroit Institute of Arts.
"It's also a show of fine arts and many artists are demonstrating how they do their work," said Willcock.
Funky Ferndale starts at 15:00 on Friday and runs until 6.00pm on Sunday. More information is available online at funkyferndaleartfair.com.
Meanwhile, on Nine Mile, the road will be closed from East Woodward to Bermuda for the DIY Street Fair.
The imprint of the street fair covers some streets and parking lots nearby and has 18 musical performances on weekends starting at 18:00. Friday.
Willcock said that 175 sellers participate in the street fair, which includes an area and activities for children, a competition of artists, food, beer and drinks.
"It's three days of great bands, food and beer," he said. "Artists and craftsmen have a lot of really beautiful things that you do not see anywhere else".
The offers at the street fair range from fine arts, folk art, engraving and photography to glass and metal works, textile ceramics and woodwork.
The do-it-yourself fair takes place every Sunday from 11 am to midnight. More information on musical performances and other activities is available online at ferndalediy.com.
Both events are free and Willcock said the city is running its free Chariot shuttle service for people who do not want to struggle looking for parking in the center or wanting to get in from the neighborhood.
"The Chariot shuttle runs in a 15-minute loop, so you never have to wait any longer for a ride," Willcock said.
The shuttles run along Nine Mile Road, Woodward and include stops at the Kulick Community Center on Livernois, he added.
The app-based service is also accessible on chariot.com.